Your Precision Gut Blueprint
The Precision Gut Blueprint is our most advanced gut assessment — six samples plus a dietitian consult, combining metagenomic microbiome sequencing, clinical stool, breath, blood, urine and DNA. Each sample has its own kit, preparation and return.
Home kits, one clinic visit, then a consult
Most samples are collected at home; the blood panel is a quick visit to an affiliated collection centre. The tests need different (sometimes opposite) preparation, so the next page sets a simple order.
What's included
- StoolMetagenomic Microbiome + BiomarkersSequencing of your gut ecosystem plus clinical markers — calprotectin, elastase, sIgA, zonulin, SCFAs, pathogens, parasites, yeasts and more.
- BreathSIBO Lactulose Breath TestTimed breath samples after a lactulose drink.
- Finger-prickFood Intolerance (IgG, 96 foods)A blood-spot card, with a Rotation Diet Guideline.
- BloodBlood panel — at a collection centreCoeliac serology, nutrient, liver, kidney & pancreatic markers, drawn at an affiliated centre.
- UrineIntestinal Permeability (Leaky Gut)A 6-hour urine collection after a sugar drink.
- Cheek swabGut DNA MarkersFUT2, HLA-DQ2.5/DQ8, DAO, MTHFR and TLR4 — genetic modifiers of gut health.
- Consult45-minute dietitian consultA qualified dietitian reviews all your results together and builds your plan.
A simple order to work through
Sort the shared preparation first, then collect the six samples across a week or two. Book the dietitian consult once your results are in. Only start or stop a medication on your practitioner's advice.
Shared preparation
- Finish antibiotics/antifungals at least 2–4 weeks before, and stop probiotics ~7 days before (where your practitioner agrees).
- Keep eating your normal, varied diet (for the food-intolerance test).
- Keep eating gluten (wheat, rye, barley) in the weeks before your blood test — going gluten-free can make the coeliac result inaccurate.
DNA cheek swab — any time
No fasting; just nothing to eat or drink in the 30 minutes before.
Food intolerance & stool — when convenient
Finger-prick any morning you're eating normally; stool on a collection day (Mon–Wed).
Blood panel — at an affiliated collection centre
Fast beforehand if advised, and keep eating gluten. Take your i-screen request form.
SIBO, then leaky gut — two separate fasting mornings
Each needs its own fasting morning — never the same day.
Dietitian consult — once results are ready
Book your 45-minute session when your dashboard shows results are complete.
Two rules that matter
Keep SIBO and leaky gut on different days (both use lactulose + a fasting morning), and don't go gluten-free before the blood test.
The stool sample
Before you collect
- Antibiotics/antifungals finished 2–4 weeks ago; probiotics stopped ~7 days ago.
- Collect on a Monday, Tuesday or Wednesday so it isn't in transit over a weekend.
- Don't collect if you have active diarrhoea from a stomach bug, or while menstruating.
- Catch the stool so it doesn't touch toilet water or urine — for example on clean paper laid over the bowl.
- Fill each collection tube as labelled — scoop from a few different spots into the preservative tubes up to the fill line, and use the swab for the swab tube. Replace and tighten every cap.
- Label every tube with your name, date of birth and the date & time, then seal them in the specimen transport bag.
Refrigerate — never freeze
Once collected and labelled, keep your stool tubes in the fridge until you post them, then send the same day. Freezing damages the sample.
Before you post — quick check
- All tubes filled to the line, capped and labelled
- Refrigerated, sealed in the transport bag, posting on a Mon–Wed
The breath test
Before your test morning
- 2–4 weeks: finished antibiotics/antifungals. 7 days: no laxatives or probiotics.
- The day before: eat only plain foods (plain chicken/fish, white rice, eggs, clear broth); then fast 12 hours (water only).
- 1 hour before / during: no smoking, sleeping, vigorous exercise or toothpaste. Do it on a Sun–Tue morning.
- Brush your teeth and tongue without toothpaste and rinse. Mix the lactulose solution and set it aside.
- Take your baseline breath sample (0 min) into the first tube before drinking, then drink the whole solution within 5 minutes and note the time.
- At each time below, take a sample: fill the bag with a normal exhale, press the tube onto the needle so it fills, remove within ~2 seconds, and bag it. Never open the tube caps.
| Sample | After drinking the lactulose | Your time |
|---|---|---|
| 1 — baseline | before drinking | — |
| 2–7 | 30 / 60 / 90 / 120 / 150 / 180 min | — |
The finger-prick blood spot
Before you collect
- Keep eating your normal, varied diet — including the foods you'd like tested. Do not fast for this one.
- Strictly avoid any food that has previously caused a serious reaction or anaphylaxis.
- Steroids, antihistamines and anti-inflammatories can affect the result — your practitioner may suggest pausing them ~4 weeks beforehand.
- Label the card in block letters (name, DOB, date) to match your request form, and unfold it without touching the circles.
- Wash your hands in warm water, dry, and wipe a fingertip with the alcohol wipe. Use a single-use lancet — press firmly and click.
- Wipe away the first drop, then let a hanging drop fall into each circle, filling every circle so it soaks through. Use the second lancet on another finger if needed, then plaster the site.
Air-dry for at least 3 hours
Prop the card up and let the blood spots dry completely for 3+ hours, away from moisture and sunlight, before you pack it.
The 6-hour urine test
Please check this first
Not suitable during pregnancy, or if you're diabetic with a fasting urine glucose over 6 mmol/L. Don't collect while menstruating.
Before you collect
- Fast from about 11 pm the night before — nothing but water for at least 8 hours.
- From the evening fast through the collection, avoid fructose (fruit, juice, honey, corn syrup) and mannitol (cauliflower, mushroom, snow peas, seaweed, watermelon, "sugar-free" gums/sweets).
- First thing, empty your bladder into the toilet and discard it — the timed collection starts after this.
- Add warm water to the brown bottle (~¾ full), shake, and drink it all. Note your start time. (30 kg or under: 2 teaspoons of the mixed solution.)
- For the next 6 hours, collect all urine into the 4-litre bag (don't tip out the preservative fluid).
- After 6 hours, note the finish time, read and record the total volume, then use the dropper to fill and label the sample tube (name, DOB, date, volume, start & finish times).
The blood panel
Keep eating gluten before this test
Your blood includes a coeliac screen. If you cut out gluten (wheat, rye, barley) first, the result can be falsely negative — so keep eating it as normal until your draw.
Before you go
- If advised, fast 8–10 hours (water only) — several markers read best fasting.
- Take your i-screen request form, and check your details on it are correct.
- Go to an i-screen affiliated collection centre — find one near you on the i-screen website. No collection fee at an affiliated centre.
- Take your request form to the centre — there's no kit to prepare, and nothing to post afterwards.
- A trained collector draws your blood; the centre and lab process it and send your results to i-screen.
What the blood panel covers
Measures: Coeliac serology · Nutrient markers · Liver function · Kidney function · Pancreatic (lipase, amylase)
The DNA cheek swab
Before you collect
- Don't eat, drink, smoke or chew gum for 30 minutes beforehand.
- Your DNA doesn't change, so this one has no timing constraints — do it whenever suits.
- Wash and dry your hands. Take a swab out without touching the soft tip.
- Rub the swab firmly against the inside of your cheek for 30–60 seconds, rotating it so it collects plenty of cells. Repeat with the second swab on the other cheek.
- Return each swab to its tube (or air-dry as your kit directs), then label them with your name, date of birth and date, and seal them in the transport bag.
What this screens
Measures: FUT2 · HLA-DQ2.5 · HLA-DQ8 · MTHFR C677T · MTHFR A1298C · DAO
Sending your samples
Each home kit has its own return packaging — post each one as you finish it. The blood panel is handled at the centre, so there's nothing to post for that.
Send each home kit as it's ready
- Stool — refrigerated, posted on a collection day.
- SIBO breath & leaky gut urine — the same day you collect.
- Food intolerance card — once fully air-dried; DNA swab — any time.
- Blood — nothing to post; the centre handles it.
- For each kit, seal the sample(s) and the completed request form / checklist in that kit's bag, then its reply-paid envelope, and post via Australia Post.
- Make sure every sample is labelled with your name, date of birth and collection date/time.
Your 45-minute dietitian consult
Once all your results are ready, book your virtual session — a qualified dietitian reviews your microbiome, genetics, gut function and food responses together and gives you a personalised gut-restoration plan.
Haven't ordered yet?
Order your Precision Gut Blueprint kits here, and view results securely in your i-screen dashboard.