Coeliac HLA typing

The HLA-DQ2.5 allele is one of the primary genetic factors associated with coeliac disease. Approximately 90-95% of individuals with coeliac disease carry either one or two copies of the HLA-DQ2.5 allele.

HLA-DQ2 is strongly associated with coeliac disease, an autoimmune disorder triggered by the consumption of gluten, found in wheat, barley, and rye. However, HLA-DQ2.2 does not appear to carry the same level of risk for coeliac disease as the more prevalent HLA-DQ2.5 allele.

Individuals who carry one or two copies of the HLA-DQ8 allele are at an increased risk of developing coeliac disease, but not all individuals with HLA-DQ8 will develop coeliac disease.