The Advanced DUTCH Check – The Game-Changer for Your Hormone Health

If you're trying to get to the root cause of your hormonal symptoms — like fatigue, mood swings, PMS, low libido, or stubborn weight gain — the Advanced DUTCH Check could be the breakthrough you’ve been looking for.

Unlike standard blood tests that only provide a snapshot of your hormones, the DUTCH test (Dried Urine Test for Comprehensive Hormones) offers a much deeper insight into how your hormones are functioning over a 24-hour period — all from four simple urine samples collected at home. The DUTCH Advanced Check is one of the most powerful tools in functional and integrative medicine today. This panel assesses 90 different markers across several hormone pathways.

So What’s Covered in the Advanced DUTCH Check?

Oestrogen Metabolism – a delicate balance

The Advanced DUTCH Check assesses oestrogen levels and their metabolic pathways, helping to identify imbalances that may contribute to symptoms like PMS, perimenopause, weight gain, and breast health concerns. The Advanced DUTCH Check also evaluates how effectively the body is detoxifying oestrogens, which is crucial for reducing the risk of hormone-sensitive conditions. The balance between the 3 types of oestrogen - oestrone (E1), oestradiol (E2), and oestriol (E3) is key to hormonal health:

• Oestradiol (E2) is the most potent and biologically active oestrogen which is essential for menstrual cycle regulation, fertility, bone health, mood, and cognition. Imbalances may lead to symptoms like PMS, heavy periods, breast tenderness, or anxiety.
• Oestrone (E1) is a weaker oestrogen which is more prevalent post-menopause. Oestrone can be converted into potentially harmful metabolites, with elevated levels contributing to oestrogen dominance or hormone-sensitive conditions if not properly detoxified.
• Oestriol (E3) is a weaker and more protective form of oestrogen which may counterbalance the effects of E1 and E.
• The Oestrogen Quotient reflects this balance — a low ratio may increase risk of oestrogen-related issues.

Progesterone Metabolism - the harmonising hormone

The Advanced DUTCH Check assesses progesterone which provide insight into how well your body is producing and metabolising this key hormone. Progesterone plays a crucial balancing role with oestrogen. It helps regulate menstrual cycles, supports implantation and pregnancy, promotes calm mood and sleep, and protects against the overstimulation effects of oestrogen.

When progesterone is low and oestrogen is relatively higher—even if oestrogen levels are technically within range—this creates a state known as oestrogen dominance. This imbalance is linked to symptoms such as:

• PMS and menstrual irregularities
• Breast tenderness or fibrocystic breasts
• Anxiety and mood swings
• Weight gain, especially around the hips and thighs
• Heavy or painful periods
• Increased risk of endometriosis and hormone-related cancers

By identifying the progesterone-to-oestrogen ratio, the Advanced DUTCH Check helps pinpoint whether oestrogen dominance is a concern and whether support through nutrition, lifestyle changes, or even hormone therapy may be beneficial. It’s especially helpful for women in perimenopause, where progesterone often drops more rapidly than oestrogen, exacerbating symptoms.

Androgens – the powerful hormones

Androgens play a vital role in both male and female health. The Advanced DUTCH Check assesses not only the production of key androgens—such as DHEA (a precursor hormone), testosterone, and DHT—but also how your body is metabolising and clearing them.

Understanding the balance and activity of androgens can provide critical insight into a wide range of issues. Elevated levels may be associated with acne, oily skin, hair loss (particularly in a male-pattern distribution), hirsutism (excess facial/body hair in women), and conditions like PCOS (Polycystic Ovary Syndrome). Low levels, on the other hand, may contribute to fatigue, low libido, poor muscle tone, low mood, and difficulty recovering from exercise.

The androgen profile helps identify whether your hormone imbalances are due to overproduction, underproduction, or poor detoxification of these powerful hormones—allowing for more targeted interventions.

Adrenal function – energy and resilience

The Advanced DUTCH Check gives a detailed view of your adrenal rhythm—how your cortisol levels rise and fall throughout the day—and how efficiently your body is producing and clearing both cortisol and its inactive form, cortisone.

A healthy cortisol rhythm peaks in the morning (to wake you up and energise you) and gradually declines throughout the day. The DUTCH test charts this curve, revealing whether your pattern is too flat, too high, or reversed—all of which may explain symptoms like fatigue, insomnia, anxiety, mid-afternoon crashes, or wired-but-tired energy at night.

The inclusion of cortisol metabolites adds another layer by showing how quickly cortisol is being broken down, which can help differentiate between low adrenal output and rapid cortisol clearance. This information is essential for assessing adrenal function and HPA axis health, especially for people experiencing chronic stress, burnout, sleep disturbances, or inflammatory issues. By understanding your unique stress hormone rhythm and clearance, you can better tailor lifestyle interventions, adaptogens, and nutrient support to restore adrenal resilience and energy.

Melatonin – sleep hygiene

Melatonin is your body’s sleep hormone, produced in response to darkness. It plays a key role in regulating your sleep–wake cycle, promoting deep, restorative sleep, and protecting your body from oxidative stress.

The Advanced DUTCH Check measures melatonin in the urine, giving insight into how much melatonin your body produces overnight. Low levels can contribute to poor sleep quality, difficulty falling or staying asleep, and disrupted circadian rhythms — especially common in people with stress, shift work, screen overexposure at night, or ageing.

Because melatonin is also a powerful antioxidant and immune regulator, this marker has broader implications for immune health, mitochondrial function, and inflammation. Knowing your melatonin status can help you fine-tune your light exposure, bedtime routine, or consider targeted supplements to support healthy sleep and recovery.

Environmental Toxins and the impact on Hormone Health

One standout feature of the Advanced DUTCH Check is its ability to assess exposure to endocrine-disrupting chemicals (EDCs). These are substances—including certain heavy metals, plastics, and industrial compounds—that can interfere with the body’s natural hormone production, signalling, and detoxification pathways.

This panel measures key disruptors such as Bisphenol A (BPA), PFAS compounds (including PFOA and PFOS), and toxic metals like arsenic, cadmium, lead, chromium, mercury, aluminium, and nickel. These compounds are known to mimic or block hormone activity, contribute to oxidative stress, and disrupt metabolic and reproductive health.

By including this testing, the Advanced DUTCH Check offers a more complete picture of hormone imbalance causes, especially when symptoms persist despite normal hormone levels. Identifying your toxic burden can help tailor nutritional, lifestyle, and detoxification strategies that support both hormone balance and overall wellbeing.

Deep Dive into Nutritional & Metabolic Health

Unlike other DUTCH tests on the market, our Advanced DUTCH Check goes beyond hormones to include key nutritional organic acids—compounds that reveal how well your body is producing energy, metabolising neurotransmitters, and processing essential vitamins. These markers offer a unique window into nutrient deficiencies (like B vitamins), oxidative stress, and mitochondrial function—all of which play a foundational role in your energy, mood, and overall resilience.

This part of the test helps connect the dots between low energy, brain fog, mood imbalances, and hidden metabolic issues. By identifying blocks in these pathways, you can take targeted action with nutrients and lifestyle adjustments to support your body's cellular health and vitality.

In Summary, our Advanced DUTCH Check goes the extra mile by offering:

• A comprehensive analysis of reproductive and adrenal hormones, including oestrogens, progesterone, testosterone, DHEA, and cortisol.
• Insight into your body’s detoxification pathways and oestrogen metabolism, highlighting potential areas for nutritional or lifestyle support.
• A clear connection between your hormone patterns and symptoms related to mood, energy, brain function, and sleep quality.
• A window into nutritional status and metabolic function, assessing key organic acids linked to B vitamins, neurotransmitters, and oxidative stress.
• An in-depth look at how your body breaks down and clears hormones, providing personalised insights for reducing toxic load and improving balance.

Why This Test Is Different

With our Advanced DUTCH Check, i-screen makes your hormone data easier to understand and act on. You’ll receive a clear, easy-to-follow report with expert interpretation of your results. If you're looking for next steps, you can book a Nutrition Assessment for tailored guidance on diet and a personalised supplement prescription based on your profile. This expert support helps you implement safe, evidence-based strategies to restore hormone balance and improve your health.

Whether you’re dealing with PMS, PCOS, perimenopause, low libido, anxiety, or fatigue — the Advanced DUTCH Check could be your most powerful tool yet for understanding your body and regaining balance.

👉 View a demo of our Advanced DUTCH Check or order your test here.