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H. Pylori: The Stomach Bug Behind a Lot of Reflux and Ulcers

24 September 2026Lindi Collett (B.Dietetics)

If you've been dealing with bloating, a burning stomach ache, or upper abdominal discomfort that keeps coming back, there's a common culprit worth ruling out: Helicobacter pylori, or H. pylori for short. It's a type of bacteria that lives in the stomach lining and is one of the most common chronic bacterial infections worldwide, affecting roughly 40-50% of adults globally, though prevalence in Australia is lower, at around a quarter of the general population, and varies significantly by community and background [1,2]. Many people carry it without ever knowing, since it often causes no symptoms at all. But when it does cause trouble, it's linked to some of the most common upper digestive complaints people deal with.

This guide covers what H. pylori is, the symptoms associated with it, and how to test for it in Australia.

What is H. pylori?

H. pylori is a spiral-shaped bacterium that burrows into the protective mucus lining of the stomach. Once established, it can disrupt the stomach's normal acid balance and irritate the lining. It remains a well-established cause of chronic gastritis and a major cause of peptic ulcers, although its relative contribution to ulcers has declined in many countries as NSAID-related (anti-inflammatory painkiller) and idiopathic ulcers have become more common [3,4,5]. Many people carry it for years without knowing, since it doesn't always cause obvious symptoms.

Symptoms linked to H. pylori

H. pylori infection can cause non-specific symptoms, but it's worth knowing that these overlap considerably with other causes of upper-gut discomfort (known collectively as dyspepsia), and symptoms alone cannot confirm or exclude infection [6]. When symptoms do occur, they may include:

  • Upper abdominal burning or gnawing pain
  • Bloating and a feeling of fullness
  • Nausea
  • Early fullness after only small meals

It's also worth clearing up a common misconception: while H. pylori has long been associated with reflux, the relationship is complex and not fully understood. Some studies suggest infection may be associated with fewer reflux symptoms rather than more, and eradicating the bacteria does not reliably change reflux outcomes [7,8]. That said, the evidence isn't uniform, some research has instead pointed to a positive link between infection and reflux, so the picture remains genuinely mixed [9]. Either way, reflux on its own is not a reliable sign of H. pylori.

Because these symptoms overlap with everyday indigestion, IBS, and other gut issues, H. pylori often goes untested for longer than it needs to.

How is H. pylori tested?

Testing for H. pylori doesn't require anything invasive. Two accessible, non-invasive options are available:

  • Stool antigen test, a simple at-home stool sample that checks for H. pylori antigens, giving a clear positive or negative result. Available as the Helicobacter Pylori Stool Test.
  • Breath test, a non-invasive breath sample that detects by-products of active H. pylori infection. Available as the Helicobacter Pylori Breath Test.

One important note on accuracy: testing should ideally be done after stopping proton pump inhibitors (a common type of acid-reducing medication) for at least 2 weeks, and antibiotics or bismuth for at least 4 weeks, since these can cause false-negative results. Some US guidance advises a longer PPI washout of up to 30 days [3,10,11]. If you're on any of these, it's worth factoring in that timing before you test.

Both tests can be ordered online and completed from home, with results available through your dashboard.

What happens if I test positive?

A positive result means H. pylori has been detected and is worth discussing with your GP. Treatment typically involves a combination of antibiotics (often three, given as part of what's called bismuth-based quadruple therapy) along with an acid-reducing medication, most commonly for 14 days under current guidance, though shorter courses were allowed in the past. The specific combination depends on local antibiotic resistance patterns [9,11,12]. A follow-up breath or stool test at least 4 weeks after finishing treatment confirms whether the infection has cleared, and a repeat course may be needed if it hasn't [9]. Your GP can confirm the right next steps for you.

Why does it matter?

For most people, H. pylori causes no problems at all. But long-standing, untreated infection is associated with an increased risk of peptic ulcers and, less commonly, more serious conditions such as stomach cancer or a rare stomach lymphoma, though it's important to stress that most infected people never develop these complications [9]. That's the reason it can be worth identifying and clearing rather than leaving it unchecked.

Why test rather than guess?

Stomach discomfort has plenty of possible causes, diet, stress, other digestive conditions, and H. pylori is just one of them. Testing gives you, and your GP, a clear answer, rather than working through elimination diets or over-the-counter remedies that may not address the underlying cause.

If your symptoms sound familiar, testing is a straightforward first step. Explore the full range of gut health tests if you'd like to look at digestion more broadly, alongside H. pylori.

This article is general information, not medical advice, and doesn't replace a consultation with your doctor. Always discuss your symptoms and results with your GP or healthcare provider.

Image of Lindi Collett (B.Dietetics)
Lindi Collett (B.Dietetics)

Lindi is i-screen's dietitian with a strong focus on nutrigenomics, chronic disease prevention, and personalised health strategies. With over 15 years of experience, she specialises in interpreting genetic insights to empower clients to optimise their wellness through tailored nutrition and lifestyle interventions. As part of the i-screen team, Lindi is dedicated to bridging the gap between genetic potential and practical health solutions.

References:
  1. Chen YC, Malfertheiner P, Yu HT, et al. Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology. 2024;166(4):605-619. doi:10.1053/j.gastro.2023.12.022.
  2. Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153(2):420-429. doi:10.1053/j.gastro.2017.04.022.
  3. Almadi MA, Lu Y, Alali AA, Barkun AN. Peptic ulcer disease. Lancet. 2024;404(10447):68-81. doi:10.1016/S0140-6736(24)00155-7.
  4. Arroyo MT, Forne M, de Argila CM, et al. The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe. Helicobacter. 2004;9(3):249-54. doi:10.1111/j.1083-4389.2004.00219.x.
  5. Vakil N. Peptic ulcer disease: a review. JAMA. 2024;332(21):1832-1842. doi:10.1001/jama.2024.19094.
  6. Chey WD, Howden CW, Moss SF, et al. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2024;119(9):1730-1753. doi:10.14309/ajg.0000000000002968.
  7. Zamani M, Alizadeh-Tabari S, Hasanpour AH, Eusebi LH, Ford AC. Systematic review with meta-analysis: association of Helicobacter pylori infection with gastro-oesophageal reflux and its complications. Aliment Pharmacol Ther. 2021;54(8):988-998. doi:10.1111/apt.16585.
  8. Qian B, Ma S, Shang L, Qian J, Zhang G. Effects of Helicobacter pylori eradication on gastroesophageal reflux disease. Helicobacter. 2011;16(4):255-65. doi:10.1111/j.1523-5378.2011.00846.x.
  9. Chen J, Zhang J, Ma X, et al. Causal relationship between Helicobacter pylori antibodies and gastroesophageal reflux disease (GERD): a mendelian study. PLoS One. 2023;18(12):e0294771. doi:10.1371/journal.pone.0294771.
  10. Crowe SE. Helicobacter pylori infection. N Engl J Med. 2019;380(12):1158-1165. doi:10.1056/NEJMcp1710945.
  11. Matthews HC, Alexander JT. Treatment of Helicobacter pylori infection. JAMA. 2026;335(18):1628-1629. doi:10.1001/jama.2026.0663.
  12. Fallone CA, Moss SF, Malfertheiner P. Reconciliation of recent Helicobacter pylori treatment guidelines in a time of increasing resistance to antibiotics. Gastroenterology. 2019;157(1):44-53. doi:10.1053/j.gastro.2019.04.011.

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