The NeuroMetabolic Stress Profile is a simple urine analysis that uncovers how the body is producing energy, managing detoxification, balancing neurotransmitters, and supporting the gut–brain axis. Research shows that individuals with autism experience metabolic stress in these pathways.
A Window Into the Body’s Metabolic Pathways
Recent research has found that individuals with autism often show distinctive patterns in organic acids - key indicators of cellular and metabolic function. Differences in metabolites involved in mitochondrial energy production, neurotransmitter metabolism, and gut microbial activity can signal underlying metabolic stress. By measuring these markers, the NeuroMetabolic Stress Profile can provide insight into how well the body is generating energy, regulating brain chemistry, and maintaining gut balance. This helps identify modifiable metabolic abnormalities that may be influencing behaviour, learning, mood, sleep, or digestive health.
Identifying Metabolic Factors That Can Be Supported
Multiple studies highlight that metabolic dysfunction - such as impaired mitochondrial activity, oxidative stress, dysbiosis, or nutrient deficiencies - can be present in individuals with ASD. These factors are measurable and, importantly, may be responsive to targeted nutritional and metabolic interventions. Research shows that addressing metabolic stress through personalised nutrition, supplementation, and dietary changes can lead to improvements in cognition, behaviour, and overall wellbeing. The NeuroMetabolic Stress Profile helps pinpoint these biochemical needs, guiding a tailored approach to support each individual’s unique biology.
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What's included
Energy Metabolism
Organic acids such as lactate, pyruvate, succinic acid, and fumaric acid help show how well the body is producing energy. When these markers are out of balance, it can suggest that the mitochondria—our cells’ energy factories—aren’t working efficiently. Many children with Autism Spectrum Disorder (ASD) show patterns of mitochondrial stress, which may contribute to fatigue, behaviour changes, or developmental challenges.
This urine test measures:
B-Complex Vitamins & Amino Acid Markers
Your B-vitamins contribute to almost every metabolic process. These markers help detect where additional B1, B2, B3, B5, B6, or biotin may be needed to aid with symptoms like fatigue or hormonal imbalance.
This urine test measures:
Fatty Acid Oxidation
Markers such as adipic acid, suberic acid, and ethylmalonic acid can point to difficulties in fatty acid oxidation, one of the body’s major energy pathways. When these pathways are impaired, energy production becomes less efficient, contributing to metabolic stress, something frequently noted in individuals with ASD.
This urine test measures:
Neurotransmitter Metabolism
Organic acids like homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid reflect how the body is producing and breaking down key neurotransmitters. Imbalances in these chemicals can influence behaviour, mood, attention, and cognitive function. Many individuals with ASD show unique patterns in these neurotransmitter metabolites.
This urine test measures:
Oxidative Stress Markers
Markers like 8-hydroxy-deoxyguanosine indicate levels of oxidative stress - cellular damage caused by an imbalance between antioxidants and free radicals. Oxidative stress is widely recognised in ASD research and may worsen behavioural, cognitive, and metabolic symptoms.
Gut Health Markers
Compounds such as indoleacetic acid, p-cresol, and 4-hydroxyphenylacetic acid reflect activity from gut bacteria and yeast. Elevated levels may indicate gut dysbiosis - an imbalance in the gut microbiome that is commonly observed in ASD. Dysbiosis can contribute to inflammation, digestive symptoms, and increased metabolic stress.
This urine test measures:
Nutritional Biomarkers
You might be eating a healthy diet or taking supplements, but is your body actively utilising those nutrients? This panel assesses your functional need for vital nutrients by examining how your cells are metabolising them.
This urine test measures:
Detoxification Indicators
Measuring these organic acids provides insights into liver detoxification efficiency and environmental toxin exposure. They can also detect oxidative damage , as well as issues in mitochondrial function.
This urine test measures:
Oxalate Metabolites
Oxalates are naturally occurring substances in foods like spinach and almonds, however, when your gut flora is out of balance, excess oxalates are absorbed, which can cause joint pain, urinary discomfort, skin rashes, fatigue, or brain fog.
This urine test measures:
Test instructions
You’ll receive your urine test kit in the mail, along with logistics for your sample collection.
Results for this test typically available in 2-3 weeks and will be published in your online dashboard.
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