Precision Cognitive Health Assessment
What’s Included in Your Assessment
Your assessment brings together an extensive suite of biomarkers spanning inflammation, metabolic health, hormones, nutrients, oxidative stress, and environmental toxins—along with key dementia-specific tests such as p-tau217 and ApoE genotype. These results are combined with optional brain imaging and detailed cardiovascular risk markers to reveal the underlying biochemical patterns influencing your cognitive performance. Every test is chosen for its ability to measure reversible drivers of brain ageing long before symptoms appear.
Your Personalised Cognitive Health Plan
After your teleconsultation and ACE-III cognitive evaluation, you will receive a fully personalised plan designed to optimise memory, focus, mood, and long-term brain resilience. Your clinician will explain each biomarker in plain language, highlight your greatest areas of opportunity, and map out targeted nutrition, lifestyle, supplementation, and medical strategies. This structured, evidence-based plan ensures you have clear next steps—and ongoing support—to protect your cognitive health with confidence.
What's included
Core dementia biomarkers provide the most direct insight into early Alzheimer’s-related changes in the brain. These blood-based markers, including phosphorylated tau (p-tau217), can measure abnormal protein changes years before symptoms emerge. Measuring these markers helps identify individuals at higher risk, supports early diagnosis, and guides personalised prevention strategies.
Brain imaging reveals the structural health of the brain. A head MRI can measure signs of brain shrinkage, white-matter changes, microvascular injury, and other structural issues that contribute to memory decline. Imaging is often used alongside blood biomarkers to create a more complete picture of brain health.
Genetic testing identifies inherited factors that influence dementia risk. ApoE genotyping examines the presence of the ApoE ε4 allele, the strongest genetic predictor of late-onset Alzheimer’s disease. Knowing your genetic profile empowers proactive lifestyle, nutritional, and medical strategies to protect long-term cognitive health.
Chronic inflammation and cardiovascular stress significantly increase dementia risk. Markers such as hsCRP, cytokines, homocysteine, troponin, and NT-proBNP highlight hidden inflammation, endothelial dysfunction, or cardiac strain. Because inflammation accelerates brain aging, targeting these processes is a central part of dementia-prevention care.
Metabolic health is one of the strongest modifiable predictors of cognitive decline. Insulin resistance, dyslipidaemia, and high blood sugar disrupt brain energy supply and promote inflammation. Measuring glucose, HbA1c, fasting insulin, lipids, Lipoprotein(a), and ApoA1/ApoB helps identify early metabolic dysfunction so it can be corrected before it impacts the brain.
Hormones influence memory, mood, focus, sleep, and metabolic rate—all essential for brain health. Thyroid hormones, sex hormones (testosterone, oestradiol), IGF-1, and adrenal markers (cortisol and DHEA-S) can all mimic or worsen cognitive symptoms when imbalanced. Testing helps optimise hormonal patterns that support cognitive clarity and emotional wellbeing.
Optimal nutrient status protects the brain from inflammation, oxidative stress, and accelerated ageing. Key nutrients, Vitamin B12, folate, Vitamin D, iron, copper, and zinc, play essential roles in mitochondrial function, neurotransmitter synthesis, and myelin repair. Methylation markers (including homocysteine and MTHFR genetics) identify reversible risk factors that can significantly improve cognitive performance.
Oxidative damage and mitochondrial dysfunction contribute to neuronal loss and memory decline. Markers such as 8-OHdG, CoQ10, and the Omega-3 Index evaluate the body’s antioxidant defences and energy production capacity. Improving these pathways supports brain resilience, healthy ageing, and long-term cognitive vitality.
Exposure to toxic metals can impair memory, mood, and neurological function. Testing for mercury and arsenic helps identify hidden toxic burdens that may contribute to neuroinflammation, oxidative stress, or mitochondrial disruption. Reducing toxic load can improve cognitive performance and overall health.
The liver is essential for detoxification, metabolic balance, and hormone processing. Liver function tests, including ALT, AST, ALP, GGT, bilirubin, and albumin,help uncover metabolic stress, inflammation, or impaired detoxification that may indirectly affect cognitive health. A healthy liver supports a healthy brain.
Kidney health influences toxin clearance, fluid balance, and overall metabolic stability. Markers such as creatinine, urea, urate, and phosphate provide insight into renal function, hydration status, and metabolic equilibrium. Proper kidney function supports the elimination of metabolic waste that can otherwise harm the brain.
Minerals like calcium and Vitamin D play essential roles beyond bone health—they influence immune function, mood, and cognition. Bone-related markers such as alkaline phosphatase and calcium help assess metabolic and endocrine pathways that indirectly affect brain health. Optimising mineral balance is part of a comprehensive approach to cognitive wellbeing.
Test instructions
Download and print your pathology form from your i-screen dashboard.
Fast from all food and drink (other than water) for at least 8 hours, and no more than 12 hours prior to your test.
You’ll receive your venous blood draw test kit in the mail, along with logistics for your sample collection.
Ready. Set. Go!
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