Methylation Pathways Check NEW FORMAT

Measuring these organic acids provides critical insights into metabolic health, gut function, and detoxification capacity. This methylation pathways test includes metabolite markers to indicate efficiency of neurotransmitter metabolism, macro nutrient metabolism, absorption and microbial balance, energy production and mitochondrial efficiency, detoxification efficiency and toxin exposure. Knowing your needs or deficiencies can uncover needs for nutritional support such as amino acids, vitamins, and minerals and help guide dietary and lifestyle treatment plans.

Energy production involves converting proteins, carbs, and fats into ATP through processes like the Krebs cycle. Genetic mutations (such as methylation defects), nutrient deficiencies, metabolic issues, and oxidative stress can disrupt these processes, leading to issues in mitochondrial function, impaired energy production and potential health issues. Understanding these factors can help you take proactive steps to maintain efficient energy metabolism.

Methylation is essential for balancing neurotransmitters like dopamine, serotonin, and noradrenaline, which regulate mood, memory, and focus. Variations in methylation genes - such as COMT and MTHFR - may affect these pathways, leading to anxiety, depression, or brain fog. Optimising intake of B vitamins, methylated folate, or dietary and lifestyle changes may support neurotransmitter balance and brain health.

Methylation is important for controlling the immune system and repairing cells. When methylation goes wrong, it can lead to autoimmune diseases and reduce the body's ability to fight oxidative stress by disrupting antioxidant production, which is worsened by high levels of oxidative stress. This can cause inflammation and tissue damage. Identifying genetic variations in methylation via a Genetic Methylation Check helps assess your risk for conditions related to inflammation, autoimmune diseases, and oxidative stress. Organic acid metabolites can confirm if methylation defects are causing oxidative stress, reduced antioxidant production, increased cellular activity, or if other metabolic problems may be present.

Measuring levels key vitamins and co-factors is valuable for assessing nutritional status, identifying deficiencies, and understanding how effectively the body is using these essential nutrients. Each of these nutrients plays a critical role in a wide range of physiological processes.

Methylation supports gut health by regulating the genes involved in digestion, inflammation, and gut barrier function. Proper methylation helps maintain the integrity of the intestinal lining, preventing "leaky gut". Methylation also influences the production of neurotransmitters like serotonin, which play a key role in gut-brain communication. Impaired methylation can lead to inflammation, increased nutrient demand, poor nutrient absorption, and imbalances in the gut microbiome, affecting overall digestive health.

Sleep and restorative health are influenced by key genes and hormones that regulate our sleep-wake cycles, neurotransmitter breakdown, and circadian rhythms. Hormonal imbalances and lifestyle factors can disrupt these processes, impacting your ability to get restful sleep and feel rejuvenated. Knowing your genetic profile can help you optimise your nutrient intake and lifestyle to enhance sleep quality.

Methylation plays a vital role in detoxification processes, particularly in the liver - genetic variations can compromise the liver's ability to efficiently eliminate toxins, causing their accumulation and potential health issues. Measuring these organic acids provides insights into energy production efficiency, metabolic dysregulation, liver detoxification efficiency, nutrient demand/deficiency and environmental toxin exposure. They can also detect oxidative damage, as well as issues in mitochondrial function.